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Currently, a limited number of iron chelators have received approval from the FDA or are undergoing clinical trials for conditions such as iron overload-related diseases, organ damage, and transplants ( 4.2 Prospects of the pharmacodynamic element from TCM Previous studies have shown that by targeting ferroptosis, some pharmacodynamic elements from TCM have certain effects or unique advantages in retinal diseases, and have potential research value for the efficacy of related retinopathy ( 4.3 Limitations of ferroptosis targeting agents The discovery of these potential therapeutic drugs provides some new perspectives and options for the treatment of retina-related diseases

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Chronic 3-NP administration depletes ATP and NAD + levels and increases the release of ILs, TNF-α, glutamate, and iNOS [168, 169]